All eastbound lanes of U.S. 301 in Palmetto were blocked after a crash on Thursday, according to Florida 511.
Law enforcement also closed the U.S. 41 off-ramp to U.S. 301 (10th Street East).
The crash was reported shortly after 5 p.m. and occurred on U.S. 301 east of Haben Boulevard.
Injuries were reported at the scene.
Traffic in the area remained congested for more than an hour.
All lanes of U.S. 301 were reopened as of 7:15 p.m.